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It was alsodetermined that the T cell response was dependent on MHC-class II expression by thecultured melanoma cell line (Guerry 1984). Patients who fail to respond to aparticular neo-adjuvant regimen are not only subjected to the toxic effects of an inef-fective therapy, but, their tumors are potentially given time to grow and spread untilan effective regimen is initiated. As shown in the previouschapter on autoimmunity neurontin mgus prolonged T cell inflammatory responses can lead to not only thegeneration of autoimmune T cells, but also the development of cancer through chronicinflammation.
EPA 2005 Guidelines forCarcinogen Risk Assessment.
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